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KMID : 1134820090380010039
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Journal of the Korean Society of Food Science and Nutrition
2009 Volume.38 No. 1 p.39 ~ p.46
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Effect of Crude Saponins from Soybean Cake on Body Weight and Glucose Tolerance in High-Fat Diet Induced Obese Mice
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Kim Sung-Mi
Seo Kwon-Il
Park Kyung-wuk
Jeong Yong-Kee
Cho Young-Su
Kim Myung-Joo
Kim Eun-Jung
Lee Mi-Kyung
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Abstract
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This study investigated the beneficial effects of crude saponins from soybean cake on body weight and glucose
tolerance in high-fat (37% calories from fat) diet fed C57BL/6 mice. The mice were supplemented with three
doses of saponins (0.5%, 1.0%, and 1.5%, wt/wt) and 1.0% Garcinia cambogia (wt/wt), positive control for 9
weeks. The body weight, visceral fat weight and epididymal adipocyte area were significantly reduced in the saponin supplemented groups in a dose dependent manner compared to the high-fat group. Saponins did not significantly affect food intake; however, cambogia significantly lowered food intake compared to the high-fat fed control group. The crude saponins from soybean cake supplement significantly lowered plasma leptin, triglyceride and total cholesterol levels, whereas they significantly elevated the fecal excretion of triglyceide in a dose dependent manner compared to the high-fat group. Cambogia did not affect the fecal excretion of lipid in the diet-induced obese mice. Supplementation of 1.5% saponin reduced the hepatic triglyceride content compared to the high-fat group. High-fat induced glucose intolerance with the elevation of blood glucose levels compared to the normal group; however, the saponins supplement significantly improved postprandial glucose levels. After 9 weeks of being fed a high-fat diet, the mice presented with significantly increased activities of hepatic fatty acid synthase and fatty acid β-oxidation; however, saponins and cambogia normalized these activities. These results indicate that saponins from soybean cake exhibit a potential anti-obesity effect and may prevent glucose intolerance by reducing body weight and plasma lipids, increasing fecal lipid excretion and regulating hepatic lipid metabolism in high-fat fed mice.
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KEYWORD
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saponins, soybean cake, obesity, glucose tolerance, lipid
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